Information Ezatiostat Ezatiostat (TER199, TLK199, Telintra), a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1) . Ezatiostat activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis . Targets GSTP1-1 ; JNK1 ; ERK1/ERK2 In vitro Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allows the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells. In vivo Ezatiostat (TLK199) stimulates both lymphocyte production and bone marrow progenitor (colony-forming unitgranulocyte macrophage) proliferation, but only in GST π +/+ and not in GST π -/- animals. Cell Research(from reference) Cell lines：Human myeloid leukemic cells (HL60) Concentrations：2.5 μM - 50 μM Incubation Time：8 h, 24 h
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Ezatiostat
CAS number：168682-53-9 molecular formula：C27H35N3O6S
overview
compound introduction
Specs
| Chinese alias | 依扎替米沙坦 | ||
| English alias | Q27095680 | NCGC00263221-01 | NCGC00263221-05 | TER 199 | Ezatiostat | Ezatiostat [INN] | Ezatiostat(TER199; TLK199) | SCHEMBL420400 | Glycine, L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, diethyl ester, (2R)- | J-690234 | TLK199 | TLK-199 | e | ||
| CAS number | 168682-53-9 | molecular formula | C27H35N3O6S |
| molecular weight | 529.65 g/mol | Exact mass | 10mM in DMSO |
| PSA | 162.000 Ų | logp | 0.745 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
