compound introduction
Information ML390 ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia. Targets DHODH (Cell-free assay) 0.56 μM In vitro ML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia. Cell Research(from reference) Cell lines：Lys-GFP-ER-HoxA9 cells Concentrations：10 μM Incubation Time：48 h
