PTP抑制剂V，PHPS1是一种可渗透细胞的磷酸酪氨酸类似物，可作为可逆的，以活性位点为靶点，与底物竞争的Shp-2抑制剂（IC | 50 |和K | i | = 2.1和0.73 µM）。PHPS1仅在较高浓度（IC | 50 | 分别为5.4、19、30和39 µM）下抑制ECPTP，PTP1B，Shp1，分枝杆菌MptpA，甚至对PTPH1，STEP，PTPN7，PTPRK，GLEPP1或LAR2几乎没有活性。浓度高达50 µM。PTP抑制剂V，PHPS1已被证明抑制Shp-2依赖性细胞信号传导和肿瘤细胞集落的形成。 PTP inhibitor V, PHPS1 is a cell-permeable phosphotyrosine analogue, which can be used as a reversible, active site as a target, and a Shp-2 inhibitor that competes with the substrate (IC | 50 | and K | i | = 2.1 and 0.73 µM). PHPS1 inhibits ECPTP, PTP1B, Shp1, Mycobacterium MptpA only at higher concentrations (IC | 50 | 5.4, 19, 30, and 39 µM, respectively), and even almost none against PTPH1, STEP, PTPN7, PTPRK, GLEPP1 or LAR2 active. Concentrations up to 50 µM. PTP inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cell signal transduction and tumor cell colony formation.
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PTP Inhibitor V, PHPS1
CAS number：314291-83-3 molecular formula：C21H15N5O6S
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| Chinese alias | - | ||
| English alias | (E)-4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid | PTPNN1 Inhibitor | 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid | EC-PTP/PCPTP1 Inhibitor I | ||
| CAS number | 314291-83-3 | molecular formula | C21H15N5O6S |
| molecular weight | 465.45 g/mol | Exact mass | ≥95% |
| PSA | 166.000 Ų | logp | 3.700 |
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