SR0987是SR1078 的一个类似物,是 RORγt 的一个激动剂,其 EC50 值为800 nM。SR0987 可上调IL17 的表达且抑制PD-1 的表达。 SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1。
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SR 0987
CAS number:303126-97-8 molecular formula:C16H10ClF6NO2
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compound introduction
Specs
| Chinese alias | 2-氯-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯甲酰胺 | 2-氯-N-(4-(1,1,1,3,3,3-六氟-2-羟基-2-丙烷基)苯基)苯甲酰胺 | ||
| English alias | 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide | 2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide | ||
| CAS number | 303126-97-8 | molecular formula | C16H10ClF6NO2 |
| molecular weight | 397.7 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 49.300 Ų | logp | 4.600 |
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