compound introduction
24（S），25环氧胆固醇是一种氧化甾醇，是小鼠中脑腹侧最丰富的氧化甾醇。。它激活发育中的腹中脑中的肝X受体（LXRs），以诱导干细胞分化为多巴胺能神经元。 24（S），25-环氧胆固醇抑制表达LXRβ的骨髓源鼠肥大细胞的IL-6产生和脱粒。当以2.5μM的浓度使用时，它可通过CHO-7和SRD-1细胞中的3β-羟基固醇Δ24-还原酶（DHCR24 / Seladin-1）抑制去甾醇向胆固醇的转化。 24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM
