compound introduction
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC 50 of ~3 μM and a GC 50 of 15 μM. CCT129957 inhibits Ca 2+ release in squamous carcinoma cells at ~15 μM In Vitro The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact. CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: ~3 μM (Phospholipase C-γ (PLC-γ))
