compound introduction
牛磺酸胆酸（TLCA）是一种牛磺酸偶联形式的次级胆汁酸胆酸，在转染牛磺酸胆酸钠共转运肽（NTCP）的Hep3B细胞中，TLCA （75 μM）增加了caspase-3和-7的活性，而未转染Hep3B细胞则没有。它已被用于体外和体内肝细胞胆汁淤积动物模型诱导胆汁淤积。在人类口服脂质耐量试验中，血清TLCA水平在两小时内增加约5倍。 Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acidTLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells. It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis. Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.
