CAS number：1954650-11-3 molecular formula：C13H8N2O2S
JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC 50 s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1 , PTP4A2 , PTP4A3 , CDC25B , and DUSP3 , respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth Form:Solid IC50& Target:IC50: 29.1 nM (PTP4A1), 48.0 nM (PTP4A2), 34.7 nM (PTP4A3), 92.6 nM (CDC25B), 207.6 nM (DUSP3)
| Chinese alias | - | ||
| English alias | 1954650-11-3 | 7-imino-2-phenyl-4H,5H,6H,7H-thieno[3,2-c]pyridine-4,6-dione | HY-135457 | Thieno[3,2-c]pyridine-4,6(5H,7H)-dione, 7-imino-2-phenyl- | PD128069 | 7-imino-2-phenylthieno[3,2-c]pyridine-4,6-dione | compound 13 [PMID: 33766767] | NSC804570 | N | ||
| CAS number | 1954650-11-3 | molecular formula | C13H8N2O2S |
| molecular weight | 256.28 g/mol | Exact mass | - |
| PSA | 98.300 Ų | logp | 2.400 |
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