Moracin C

Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells In Vitro Moracin C (1-50 μM, 24 h) inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from RAW264.7 cells. Moracin C (1-50 μM, 2 h) inhibits mRNA and protein expression of iNOS and COX-2 in RAW264.7 cells. Moracin C (1-50 μM, 2 h) inhibits pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) productions in LPS-activated RAW 264.7 cells. Moracin C (1-50 μM, 2 h) inhibits phosphorylation of p38, ERK and JNK in LPS-activated RAW 264.7 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. RT-PCRCell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced mRNA expression of iNOS and COX-2. Western Blot AnalysisCell Line: RAW 264.7 macrophages Concentration: 1, 10, 25, 50 μM Incubation Time: 2 h Result: Inhibited LPS-induced TLR4 expression and NF-κB activation. Reduced phosphorylated p38, ERK and JNK levels. In Vivo Moracin C (100 mg/kg, oral gavage, mice) was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice (PK Assay)Dosage: 100 mg/kg Administration: Oral gavage Result: Pharmacokinetic profile of Moracin C. Parameters Terminal half-life (min) C max (μg/mL) T max (min) CL R (mL/min/kg) 100 mg/kg 256 1.79 15 0.032 Form:Solid IC50& Target:COX-2

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