TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP50 Appearance:Solid In Vitro:TP508 (50 μg/mL; 24 hours; HCAEC) treatment reverses radiation-induced endothelial dysfunction (ED) and loss of NO signaling by attenuating the downregulation of eNOS expression. TP508 treatment is able to stimulate NO production in the irradiated cells. In Vivo:TP508 (10mg/kg; intravenous injection; male CD-1 mice) treatment mitigates radiation-induced endothelial cell damage, also significantly increases survival of CD-1 mice when injected 24 h after 8.5 Gy exposure . MCE has not independently confirmed th Biological Activity:TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP50
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TP508 TFA
CAS number：unknown molecular formula：C99H147N28F3O38S
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| Chinese alias | TP508 三氟乙酸 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C99H147N28F3O38S |
| molecular weight | 2426.46 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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