CAS number：162831-31-4 molecular formula：C16H30N2·2HBr
IEM-1754是一种金刚烷衍生物，是天然离子性谷氨酸受体开放通道的有效阻遏剂，包括昆虫肌肉中的准质敏感受体，培养的大鼠皮层神经元中的 NMDAR，以及新鲜分离的海马细胞中的 AMPAR。IEM-1754在体内具有抗惊厥作用。 Product description IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo.
| Chinese alias | N1-(金刚烷-1-基甲基)戊烷-1,5-二胺二氢溴化物 | ||
| English alias | IEM-1754 | IEM 1754 dihydrobromide | N1-(adamantan-1-ylmethyl)pentane-1,5-diaminedihydrobromide | N1-((3r,5r,7r)-adamantan-1-ylmethyl)pentane-1,5-diamine dihydrobromide | ||
| CAS number | 162831-31-4 | molecular formula | C16H30N2·2HBr |
| molecular weight | 412.2 g/mol | Exact mass | ≥98% |
| PSA | 38.100 Ų | logp | - |
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