compound introduction
VU0364770 hydrochloride is a selective and potent positive allosteric modulator ( PAM ) of mGlu4 . VU0346770 hydrochloride exhibits EC 50 s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with K i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B , respectively Form:Solid IC50& Target:Rat mGlu 4 290 nM (EC 50 ) Human mGlu 4 1.1 μM (EC 50 ) mGlu 6 6.8 μM (EC 50 ) mGlu 5 17.9 μM (EC 50 )
