JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca 2+ -activated potassium channel 3 ( KCa2.3 ) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice. In Vivo JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: TRPV4 -/- and wild‐type C57BL/6J mice (hypertensive induced by NOS inhibitor Nω-nitro-L-arginine, AngII and high-salt diet) Dosage: 1 mg/kg Administration: IV; single dosage Result: Increased the impaired TRPV4‐KCa2.3 interaction to improve endothelium‐dependent relaxation in small resistance arteries and to lower blood pressure. Form:Solid
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JNc-440
CAS number：1119503-63-7 molecular formula：C26H24N4O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1119503-63-7 | molecular formula | C26H24N4O3 |
| molecular weight | 440.49 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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