Myxothiazol, an antifungal antibiotic , is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml. In Vitro Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml. Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/J6 miceDosage: 0.56 mg/kg Administration: I.p.; 24 hours intervals for at most 4 times Result: A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found. Form:Solid
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Myxothiazol
Dangerous GoodsCAS number：76706-55-3 molecular formula：C25H33N3O3S2
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| Chinese alias | 粘菌素 | ||
| English alias | 1sqp | UNII-6VY98BQ7NB | 2,6-HEPTADIENAMIDE, 7-(2'-((1S,2E,4E)-1,6-DIMETHYL-2,4-HEPTADIEN-1-YL)(2,4'-BITHIAZOL)-4-YL)-3,5-DIMETHOXY-4-METHYL-, (2E,4R,5S,6E)- | SCHEMBL447904 | MS-29066 | 2,6-HEPTADIENAMIDE, 7-(2'-(1,6-DIMETHYL-2,4-HEPTADIENYL)(2,4'-BITHIA | ||
| CAS number | 76706-55-3 | molecular formula | C25H33N3O3S2 |
| molecular weight | 487.68 g/mol | Exact mass | ≥99% |
| PSA | 144.000 Ų | logp | 4.800 |
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
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