compound introduction
链霉菌Streptomyces netropsis产生的抗生素。溶于水(30mg/ml，80℃，＞0.5mg/ml，25℃)，不溶于一般有机溶剂。盐酸盐吸湿性强。含n-甲基吡咯寡肽，结合到dsDNA的富AT序列上，尤其在小的凹槽位点。这样，它保护该区域免受DNase I和内切核酸酶切割，也抑制拓扑异构酶。 纺锤菌素打乱细胞分裂周期，延长G期，并使分裂停止在G期。 医药上具有抗细菌、真菌、锥体虫、牛痘病毒、噬菌体等作用。
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Netropsin dihydrochloride
CAS number：18133-22-7 molecular formula：C18H26N10O3·2HCl
overview
Specs
| Chinese alias | 纺锤菌素 | ||
| English alias | SCHEMBL10408939 | NETROPSIN CHLORIDE | Congocidine | LA 887 | ANTIBIOTIC 1A-887 | NETROPSIN DIHYDROCHLORIDE HYDRATE | N-(3-amino-3-iminopropyl)-4-[[4-[[2-(diaminomethylideneamino)acetyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carboxamid | ||
| CAS number | 18133-22-7 | molecular formula | C18H26N10O3·2HCl |
| molecular weight | 503.39 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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