Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as Ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively. Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger Ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins. UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate Ubiquitin to the tumor suppressor, p53. Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1. Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses.
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Recombinant Human UbcH5a/UBE2D1 Protein
CAS number：unknown molecular formula：
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| Chinese alias | 重组人 UbcH5a/UBE2D1蛋白 | 重组人 UbcH5a/UBE2D1 蛋白 | ||
| English alias | E2 ubiquitin-conjugating enzyme D1 | Stimulator of Fe transport (SFT) | UBC4/5 homolog | UbcH5 | (E3-independent) E2 ubiquitin-conjugating enzyme D1 (EC:2.3.2.24) | EC:2.3.2.24 | Ubiquitin-conjugating enzyme E2 D1 | (E3-independent) E2 ubiquitin-conjugati | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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