Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis , with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. In Vitro Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:ERK1 ERK2 Akt
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Deltonin
CAS number：55659-75-1(DMSO) molecular formula：C45H72O17
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| Chinese alias | 德尔托宁 | ||
| English alias | - | ||
| CAS number | 55659-75-1(DMSO) | molecular formula | C45H72O17 |
| molecular weight | 885.04 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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