Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression. In Vitro Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC 50 values >40 μM. It agaisnt wnt-dependent cells with IC 50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively. Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged. In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC 30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner. At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine's are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Coronaridine
CAS number：467-77-6 molecular formula：C21H26N2O2
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Specs
| Chinese alias | 冠状动脉造影剂 | ||
| English alias | (-)-Coronaridine | methyl (1S,15R,17S,18S)-17-ethyl-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate | NVVDQMVGALBDGE-PZXGUROGSA-N | NSC 127490 | DTXSID60963642 | Methyl ibogamine-18-carboxylate | FS-8035 | HY-1211 | ||
| CAS number | 467-77-6 | molecular formula | C21H26N2O2 |
| molecular weight | 338.44 g/mol | Exact mass | - |
| PSA | 45.300 Ų | logp | 3.5 |
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