Daun02是拓扑异构酶抑制剂Daunorubicin的前体。 Daun02 is a proagent of the topoisomerase inhibitor Daunorubicin. In vitro research Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca2+)-dependent action potentials in neuroblastoma cells. Daunorubicin is a topoisomerase inhibitor. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively In vivo research Daun02 is a good substrate for β-gal with Km and Vmax values of 0.37 mM and 8.6 μmol/min/mg protein. At a concentration of 10-5 M, Daun02 is 79% bound to plasma protein compares to 94% for Daunomycin
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Daun02
CAS number：290304-24-4 molecular formula：C41H44N2O20
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 290304-24-4 | molecular formula | C41H44N2O20 |
| molecular weight | 884.79 g/mol | Exact mass | ≥95% |
| PSA | 343.000 Ų | logp | 1.7 |
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