CAS number：915019-65-7 molecular formula：C30H23N5O
BEZ235 (NVP-BEZ235, Dactolisib) ATP竞争性的抑制PI3K和mTOR，对p110α/γ/δ/β和mTOR(p70S6K)均有抑制作用，IC50分别为4 nM/5 nM/7 nM/75 nM/6 nM，对ATR也有抑制作用，IC50为21 nM；但对Akt和PDK1抑制作用微弱。A dual PI3K and mTOR inhibitor BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively. Inhibits ATR with IC50 of 21 nM, whileshown to be a poor inhibitor to Akt and PDK1. A dual PI3K and mTOR inhibitor
| Chinese alias | - | ||
| English alias | BEZ235 | BEZ-235 | IRL-2500 is known as an ETB antagonist. | Lacidipinum | 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile | AMY2877 | CT-BEZ | HY-50673 | NVP-BEZ235 | NVP-BEZ-235 | SCHEMBL105 | ||
| CAS number | 915019-65-7 | molecular formula | C30H23N5O |
| molecular weight | 469.54 g/mol | Exact mass | - |
| PSA | 73.100 Ų | logp | 5.2 |
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