CAS number：1260251-31-7 molecular formula：C42H56F2N8O6
Birinapant (TL32711) 是一种二价 Smac 模拟物，是 XIAP 和 cIAP1 的强效拮抗剂，Kd 值分别为 45 nM 和小于 1 nM。Birinapant (TL32711) 诱导完整细胞中 cIAP1 和 cIAP2 的自身泛素化和蛋白酶体降解，从而形成 RIPK1: caspase-8 复合物，caspase-8 活化和诱导肿瘤细胞死亡。Birinapant (TL32711) 靶向与 TRAF2 相关的 cIAP，并消除 TNF 诱导的 NF-κB 活化。
| Chinese alias | - | ||
| English alias | 2,2-dimethyl-3-hydroxypropyl 2,2-dimethyl-3-hydroxypropionate | NSC767128 | NSC-767128 | D10417 | HY-16591 | (2S)-N-[(2S)-1-[(2R,4S)-2-[[6-fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]me | ||
| CAS number | 1260251-31-7 | molecular formula | C42H56F2N8O6 |
| molecular weight | 806.94 g/mol | Exact mass | - |
| PSA | 195.000 Ų | logp | 3.3 |
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