CAS number：267243-28-7 molecular formula：C24H25ClFN5O3
Canertinib (CI-1033)是一种pan-ErbB抑制剂，同时抑制EGFR和ErbB2，IC50分别为1.5 nM和9.0 nM，但对PDGFR， FGFR， InsR， PKC，和CDK1/2/4等均无抑制活性。 Canertinib (CI-1033) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. An irreversible pan-erbB tyrosine kinase inhibitor.
| Chinese alias | - | ||
| English alias | PD-183805 | EC-000.2258 | BDBM4779 | N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide | AC-28654 | Canertinib [INN] | NCGC00182713-18 | GTPL5675 | Canertinib - CI-1033 | HMS3244N17 | N-[4-(3-chloro-4-fluoro-anilino)-7- | ||
| CAS number | 267243-28-7 | molecular formula | C24H25ClFN5O3 |
| molecular weight | 485.94 g/mol | Exact mass | - |
| PSA | 88.600 Ų | logp | 3.900 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
