产品介绍： RK-33是DDX3（RNA解旋酶）的小分子抑制剂。在DDX3过表达的细胞中，引起细胞周期阻滞、诱导凋亡并促进辐射敏化作用。 Information RK-33 RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. Targets DDX3 In vitro RK-33 binds specifically to DDX3, but not to the closely related proteins DDX5 and DDX17. RK-33 inhibits cancer growth and radiosensitizes lung cancer cells in a DDX3-dependent manner. RK-33 has no effect on either mitochondrial respiration or ATP generation. RK-33 curbs proliferation and induces apoptosis in a DDX3-dependent fashion. Wnt signaling is mediated by DDX3 and inhibited by RK-33. RK-33 impairs radiation-induced DNA damage repair by inhibiting NHEJ activity. In vivo RK-33 in combination with radiation induces tumor regression in multiple mouse models of lung cancer. RK-33, at the dose used, is non-toxic in SCID mice. RK-33-treated mice do not exhibit any discernable morphological changes. Cell Research(from reference) Cell lines：MDA-MB-231 cells Concentrations：7.5 μM Incubation Time：12 h
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RK-33
CAS number：1070773-09-9 molecular formula：C23H20N6O3
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| Chinese alias | - | ||
| English alias | 2H-Diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one,3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]- | RK33 | RK 33 | RK-33 | 3,7-bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one | ||
| CAS number | 1070773-09-9 | molecular formula | C23H20N6O3 |
| molecular weight | 428.44 g/mol | Exact mass | ≥98% |
| PSA | 93.700 Ų | logp | 2.687 |
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