Corilagin是一种多酚，是单宁家族的一员，最初是从| Arctostaphylos uvaursi |的提取物中分离出来的。该化合物在76μM的IC | 50 |下具有抑制NFκB途径活化和阻止TNF-α释放的能力。其他研究表明，Corilagin可显着抑制大鼠血浆中的1型纤溶酶原激活物抑制剂（PAI-1）。还已经报道导致血浆组织型纤溶酶原激活剂（tPA）的增加，这导致了可乐菌素的溶栓作用。 Product Describtion: Corilagin is a polyphenol and a member of the tannin family that has originally been isolated from the extract of|Arctostaphylos uvaursi|. This compound displays the ability to inhibit NFκB pathway activation and also prevent the release of TNF-α at an IC|50|of 76 μM. Additional studies show that Corilagin significantly inhibits type 1 plasminogen activator inhibitor (PAI-1) in rat plasma. Also has been reported to result in an increase in plasma tissue-type plasminogen activator (tPA) which results in the thrombolytic effect of Corilagin. Product Application： Corilagin has been used to study its inhibitory effect on the growth of breast cancer by inducing apoptosis and autophagy regulated by the release of reactive oxygen species.
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Corilagin
CAS number：23094-69-1 molecular formula：C27H22O18
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | (1S,19R,21S,22R,23R)-6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.0^{4,9}.0^{10,15}]tricosa-4,6,8,10,12,14-hexaen-21-yl 3,4,5-trihydroxybenzoate | CCG-270295 | MFCD00238565 | 2088321-44-0 | s9090 | BDBM50242279 | 1-O-galloyl | ||
| CAS number | 23094-69-1 | molecular formula | C27H22O18 |
| molecular weight | 634.46 g/mol | Exact mass | ≥98% |
| PSA | 311.000 Ų | logp | 0.100 |
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MSDS
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23094-69-1 | Corilagin.pdf
