BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (K i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling. In Vivo BMS-984923 (7.5 mg/kg or 15 mg/kg, oral gavage, once) exhibits good oral bioavailability and BBB penetration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl6J male mice . Dosage: 7.5 mg/kg or 15 mg/kg (Pharmacokinetic Analysis) Administration: Oral gavage, once. Result: The plasma concentration exceeded 2 μM at 10 hr. Brain concentrations were nearly as high as plasma concentrations when measured 3 hr after a 7.5 mg/kg oral dose Form:Solid
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BMS-984923
CAS number：1375752-78-5 molecular formula：C22H15ClN2O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1375752-78-5 | molecular formula | C22H15ClN2O2 |
| molecular weight | 374.82 g/mol | Exact mass | - |
| PSA | - | logp | - |
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