compound introduction
UCN-02是从产生星形孢菌素的链霉菌培养物中分离出来的吲哚并咔唑。UCN-02是作为选择性放线菌的高产星形孢菌素生产菌株的次要共代谢物而分离的。尽管其异构体UCN-01的选择性较弱，但UCN-02的活性相当，并且可能通过相似的机制起作用。UCN-02是PKCα，PKCβ，PKCδ，PKCε和PKCγ的抑制剂。 UCN-02 is a indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-02 is isolated as a minor co-metabolite of high staurosporine-producing strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. UCN-02 is an inhibitor of PKC α, PKC β, PKC δ, PKCε and PKC γ.
