CAS number：1316214-52-4 molecular formula：C24H27N5O3
Rocilinostat (ACY-1215)是一种选择性HDAC6抑制剂， IC50为5 nM，作用于HDAC6比作用于HDAC1/2/3(I型HDACs)选择性高10倍以上，对HDAC8具有微弱的作用活性，对HDAC4/5/7/9/11， Sirtuin1和Sirtuin2具有最低限度的作用活性。 Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.
| Chinese alias | - | ||
| English alias | HY-16026 | NCGC00345802-05 | AKOS024259260 | Ricolinostat [USAN] | BDBM50439674 | Ricolinostat (USAN/INN) | Rocilinostat (ACY-1215) | 1316214-52-4 | 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide | o-methyl cyclic o,o-(methylen | ||
| CAS number | 1316214-52-4 | molecular formula | C24H27N5O3 |
| molecular weight | 433.5 g/mol | Exact mass | - |
| PSA | 107.000 Ų | logp | 3.4 |
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