CAS number：741713-40-6 molecular formula：C18H21F2N5O4S
R547是一种有效的，ATP竞争性CDK1/2/4抑制剂，Ki为2 nM/3 nM/1 nM，对CDK7和GSK3α/β作用效果稍弱，而抑制其他激酶活性。Phase 1。A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4. R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4.
| Chinese alias | - | ||
| English alias | (4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone | (4-Amino-2-{[1-(Methylsulfonyl)piperidin-4-Yl]amino}pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)methanone | R 547 | Ro 4584820 | SMR004701352 | NSC | ||
| CAS number | 741713-40-6 | molecular formula | C18H21F2N5O4S |
| molecular weight | 441.45 g/mol | Exact mass | - |
| PSA | 136.000 Ų | logp | 2.1 |
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