CAS number：405168-58-3 molecular formula：C23H22ClN5O
CHIR-124是一种新型有效的Chk1抑制剂，无细胞试验中IC50为0.3 nM。比作用于Chk2选择性高2000倍，比作用于CDK2/4和Cdc2活性高500到5000倍。 CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
| Chinese alias | - | ||
| English alias | NCGC00346626-04 | 4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One | (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one | BDBM50185219 | 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl | ||
| CAS number | 405168-58-3 | molecular formula | C23H22ClN5O |
| molecular weight | 419.91 g/mol | Exact mass | - |
| PSA | 73.100 Ų | logp | 3.5 |
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