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Chk2 inhibitor II

CAS number：516480-79-8    molecular formula：C20H14CIN3O2

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overview

compound introduction

Chk2 Inhibitor II (BML-277) 是一种Chk2的ATP竞争性抑制剂，IC50为15 nM。它对Chk2的选择性比对Chk1和Cdk1/B激酶高1000倍以上。Chk2 Inhibitor II (BML-277) 剂量依赖性地保护人CD4(+)和CD8(+)T细胞免受电离辐射导致的凋亡。

Specs

Chinese alias2-[4-(4-氯苯氧基)苯基]-3H-苯并咪唑-5-羧酰胺
English aliasRegadenoson; CVT-3146 | Chk2 Inhibitor II | BML277 | BML-277 | HMS3745A07 | NCGC00165768-02 | NSC741899 | NSC-741899 | 4a9r | ML-277 (Chk2 Inhibitor II) | AKOS000547465 | 2-(4-(4-chlorophenoxy)phenyl)-1H-benzo[d]imidazole-6-carboxamide | AS-55907 | Chk2 I
CAS number516480-79-8molecular formulaC20H14CIN3O2
molecular weight363.8 g/molExact mass-
PSA81.000 Ųlogp4.300

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