compound introduction
MK-8745是一种高度选择性Aurora-A抑制剂，IC50 为0.6 nM,其对于Aurora-A的选择性高于Aurora B的选择性450倍。
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MK-8745
CAS number：885325-71-3 molecular formula：C20H19ClFN5OS
overview
Specs
| Chinese alias | - | ||
| English alias | (3-Chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone | 1-(3-Chloro-2-fluorobenzoyl)-4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-piperazine | 6-[[4-(3-Chloro-2-fluorobenzoyl)piperazin-1-yl]methyl]-N-(thiazol-2-yl | ||
| CAS number | 885325-71-3 | molecular formula | C20H19ClFN5OS |
| molecular weight | 431.91 g/mol | Exact mass | 10mM in DMSO |
| PSA | 89.600 Ų | logp | 3.600 |
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