Information SRT2183 is a small-molecule activator of the sirtuin subtypeSIRT1, currently being developed by Sirtris Pharmaceuticals. Targets SIRT1 In vitro SRT2183 is potent with growth arrest and apoptosis induced at doses ranging from 1-20 μM. SRT2183 treatment leads to increased mRNA levels of pro-apoptosis, growth arrest, and DNA damage response genes. SRT1720, SRT2183, SRT1460, and resveratrol exhibit multiple off-target activities against receptors, enzymes, transporters, and ion channels. They are not direct activators of SIRT1. SRT2183 has little or no effect on SIRT1 deacetylating activity with native full-length substrates. SRT2183 activates AMPK, increases Sirt1 expression and decreases RelA/p65 lysine310 acetylation, critical for NF-κB activation, and an established Sirt1 target and inhibits RANKL-induced osteoclast generation and resorptive capacity in bone marrow macrophages. Cell Research(from reference) Cell lines：Bone-marrow derived macrophages(BMMs) Concentrations：1μM Incubation Time：72 h
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SRT2183
CAS number：1001908-89-9 molecular formula：C27H24N4O2S
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| Chinese alias | - | ||
| English alias | DTXSID501029656 | s8270 | SRT 2183 | SRT2183 | SRT-2183 | Q7392861 | 6FKU9G9CX6 | HY-19759 | EX-A4217 | SCHEMBL1325303 | N-[2-(3-{[(3R)-3-Hydroxy-1-pyrrolidinyl]methyl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-naphthamide | HMS3886H08 | 2-Naphthalenecarbo | ||
| CAS number | 1001908-89-9 | molecular formula | C27H24N4O2S |
| molecular weight | 468.57 g/mol | Exact mass | 10mM in DMSO |
| PSA | 98.100 Ų | logp | 3.6 |
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