SRS16-86 是一种新型的第三代 ferrostatin，是 ferroptosis 的抑制剂。 应用： SRS16-86 在体内比 Ferrostatin-1 对代谢和血浆更稳定。SRS16-86 可用于肾缺血再灌注损伤 (IRI) 和脊髓损伤 (SCI) 研究。 Information SRS16-86 SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis . In vitro SRS16-86 exhibits ferroptosis-inhibiting ability in vitro by FACS analysis of erastin-treated HT-1080 cells and in NIH 3T3 cells. In vivo SRS16-86 (a novel third-generation ferrostatin) is more stable, to metabolism and plasma, and more potent, compared with the first-in-class compound ferrostatin-1 (Fer-1) to suppress ferroptosis in vivo. Even in conditions with extraordinarily severe IRI, SRS16-86 exerts strong protection to an extent which has not previously allowed survival in any murine setting. Cell Research(from reference) Concentrations：1 μM Incubation Time：24 h, 40 h
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SRS16-86
CAS number：1793052-96-6 molecular formula：C26H32N4O2
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| Chinese alias | - | ||
| English alias | Benzoic acid,3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-,1,1-dimethylethyl ester | ||
| CAS number | 1793052-96-6 | molecular formula | C26H32N4O2 |
| molecular weight | 432.56 g/mol | Exact mass | 10mM in DMSO |
| PSA | 76.500 Ų | logp | 5.000 |
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