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Angiotensin II human Acetate

CAS number:68521-88-0    molecular formula:C50H71N13O12(free base)

overview

compound introduction

氨基酸序列:ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT 血管紧张素Ⅱ人醋酸盐 是一种血管收缩剂,是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human acetate 在调节人类血压中起着核心作用,主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。血管紧张素Ⅱ人醋酸盐刺激交感神经刺激,增加醛固酮生物合成和肾脏活动。血管紧张素Ⅱ人醋酸盐诱导血管平滑肌细胞生长,增加成纤维细胞中 I 型和 III 型胶原的合成,导致血管壁和心肌增厚,并导致纤维化。血管紧张素Ⅱ人醋酸盐也诱导细胞凋亡。血管紧张素Ⅱ人醋酸盐通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。 Information Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.

Specs

Chinese alias-
English alias4-Hydroxy-N-phenylaniline | Angiotensin II acetate [USAN] | ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT | NSC-53476 | Angiotensin II human acetate | SCHEMBL1585377 | AKOS040759453 | Angiotensin II, 5-L-isoleucine-, monoacetate (salt) | D11142 | MFCD00133
CAS number68521-88-0molecular formulaC50H71N13O12(free base)
molecular weight1046.18(free base) gExact mass≥98%
PSA446.000 Ųlogp-

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