氨基酸序列:ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT 血管紧张素Ⅱ人醋酸盐 是一种血管收缩剂,是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human acetate 在调节人类血压中起着核心作用,主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。血管紧张素Ⅱ人醋酸盐刺激交感神经刺激,增加醛固酮生物合成和肾脏活动。血管紧张素Ⅱ人醋酸盐诱导血管平滑肌细胞生长,增加成纤维细胞中 I 型和 III 型胶原的合成,导致血管壁和心肌增厚,并导致纤维化。血管紧张素Ⅱ人醋酸盐也诱导细胞凋亡。血管紧张素Ⅱ人醋酸盐通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。 Information Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.
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Angiotensin II human Acetate
CAS number:68521-88-0 molecular formula:C50H71N13O12(free base)
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| Chinese alias | - | ||
| English alias | 4-Hydroxy-N-phenylaniline | Angiotensin II acetate [USAN] | ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT | NSC-53476 | Angiotensin II human acetate | SCHEMBL1585377 | AKOS040759453 | Angiotensin II, 5-L-isoleucine-, monoacetate (salt) | D11142 | MFCD00133 | ||
| CAS number | 68521-88-0 | molecular formula | C50H71N13O12(free base) |
| molecular weight | 1046.18(free base) g | Exact mass | ≥98% |
| PSA | 446.000 Ų | logp | - |
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