CAS number：942918-07-2 molecular formula：C30H33N7O
GSK1070916是可逆的ATP竞争性Aurora B和C抑制剂，IC50分别为3.5 nM和6.5 nM。而对于Aurora A-TPX2复合物的IC50则为490 nM。 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex.
| Chinese alias | - | ||
| English alias | HY-70044 | AKOS005145558 | GTPL8358 | 3-(4-(4-(2-(3-((DIMETHYLAMINO)METHYL)PHENYL)-1H-PYRROLO(2,3-B)PYRIDIN-4-YL)-1-ETHYL-1H-PYRAZOL-3-YL)PHENYL)-1,1-DIMETHYLUREA | 8VLB51V7HO | NCGC00346648-10 | compound 17k [PMID 20420387] | MFCD22420815 | F17366 | s274 | ||
| CAS number | 942918-07-2 | molecular formula | C30H33N7O |
| molecular weight | 507.63 g/mol | Exact mass | - |
| PSA | 82.100 Ų | logp | 3.9 |
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