CAS number：1197996-80-7 molecular formula：C21H24N2O2
CBL0137 (Curaxin-137)是一种 histone chaperone FACT (facilitates chromatin transcription) 的抑制剂，可同时抑制 NF-κB 并激活 p53，对应的EC50值分别为0.47 μM和0.37 μM。 Information CBL0137 CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively. Targets FACT ; p53 (Cell-free assay); NF-κB (Cell-free assay) ; 0.37 μM(EC50); 0.47 μM(EC50)
| Chinese alias | - | ||
| English alias | Pentaerythritol, sodium salt | 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone | 1-[6-acetyl-9-[2-(isopropylamino)ethyl]carbazol-3-yl]ethanone | cbl0137 | CBL-0137 | CBL-0137; CBL 0137; Curaxin 137 | 1197996-80-7 | Curaxin 137 | CBLC1 | ||
| CAS number | 1197996-80-7 | molecular formula | C21H24N2O2 |
| molecular weight | 336.43 g/mol | Exact mass | ≥98% |
| PSA | 51.100 Ų | logp | 3.338 |
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