Information LY2409881 is a potent and selectiveIKK2inhibitor withIC50of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Targets IKK2 30 nM In vitro LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth. In vivo In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth. Cell Research(from reference) Cell lines：OCI-LY10 cells Concentrations：25 μM Incubation Time：~72 h
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LY2409881 trihydrochloride
CAS number：946518-60-1 molecular formula：C24H32Cl4N6OS
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| Chinese alias | LY2409881 三盐酸盐 | ||
| English alias | 2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride | ||
| CAS number | 946518-60-1 | molecular formula | C24H32Cl4N6OS |
| molecular weight | 594.43 g/mol | Exact mass | ≥97% |
| PSA | 102.000 Ų | logp | - |
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