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Mivebresib

CAS number：1445993-26-9    molecular formula：C22H19F2N3O4S

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overview

compound introduction

Mivebresib (ABBV-075) 是一种新型的 BET family bromodomain 抑制剂。以相似的亲和力结合BRD2/4/T的溴区(Ki值在1-2.2 nM间)，具有高度选择性。对BRD3的效力比较低(Ki=12.2 nM)，对CREBBP具有中等活性(Ki=87 μM)。Mivebresib(ABBV-075) 可有效地触发多种肿瘤细胞的凋亡。

Specs

Chinese alias-
English aliasMivebresib [USAN] | Mivebresib; ABBV-075 | Mivebresib | SCHEMBL15068241 | AKOS030628486 | N-[4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]ethanesulfonamide | N-[4-(2,4-difluorophenoxy)-3-{6-methyl-7-oxo-1H,6H,7H-pyrrolo[2
CAS number1445993-26-9molecular formulaC22H19F2N3O4S
molecular weight459.47 g/molExact mass-
PSA99.900 Ųlogp2.900

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