compound introduction
SGI-1027 是 DNA 甲基转移酶 (DNMT) 抑制剂，对以 poly(dI-dC) 为底物的 DNMT3B，DNMT3A 和 DNMT1 的 IC50 值分别为 7.5 μM，8 μM 和 12.5 μM。 Application： SGI-1027 has been used as a DNA methyltransferase inhibitor to study its effects on gene expression during osteogenic differentiation. It has also been used as a DNA methyltransferase 3a inhibitor to study its effects on interleukin-6 (IL-6)-induced loss of forkhead box P3 (Foxp3) gene expression in B-lymphocyte-induced maturation protein 1 (Blimp1)-Treg cells.
