CAS number：1228108-65-3 molecular formula：C42H40N2O8
Sabutoclax 是有效的 Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) 抑制剂， IC50 值分别为 0.32 μM， 0.31 μM， 0.20 μM， 0.62 μM。Sabutoclax 提高 Bax、Bim、PUMA 和 survivin 的表达。 Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression.
| Chinese alias | (1R)-1,1',6,6',7,7'-六羟基-3,3'-二甲基-N5,N5'-双((2R)-2-苯基丙基)-[2,2'-[联萘]-5,5'-二甲酰胺 | ||
| English alias | 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide | BI-97C1 | (1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide | ||
| CAS number | 1228108-65-3 | molecular formula | C42H40N2O8 |
| molecular weight | 700.78 g/mol | Exact mass | - |
| PSA | 180.000 Ų | logp | 8.900 |
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