Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC 50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment. In Vitro Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC 50 values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells. Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro. Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer. Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells. Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: K562 Myeloid Leukemia Cells. Concentration: 0-500 μM. Incubation Time: 1 h or 24 h. Result: When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM. Form:Solid
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Pyrazoloacridine
CAS number：99009-20-8 molecular formula：C19H21N5O3
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| Chinese alias | 吡唑并吖啶 | ||
| English alias | L24XJN68OW | PD 115,934 | N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine | BRN 4211902 | DB12549 | AKOS024419418 | PD-115934 | Neuro_000206 | Q27282607 | 3-Amino-5-methoxybenzotrifluoride; 5-Trifluoromethyl-m-anisidine | Pyrazo | ||
| CAS number | 99009-20-8 | molecular formula | C19H21N5O3 |
| molecular weight | 367.40 g/mol | Exact mass | ≥98% |
| PSA | 88.100 Ų | logp | 3 |
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