CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) ( K i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC 50 s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1 , HIPK2 ( homeodomain-interacting protein kinase 2 ), and DYRK1A with K i s of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy In Vitro CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Jurkat cells Concentration: 0-50 µM Incubation Time: 24 hours Result: Inhibited cell growth in a dose-dependent manner. Form:Solid IC50& Target:CK2 0.5 μM (IC 50 ) CK2 0.25 μM (Ki) ERK8 0.5 μM (IC 50 ) PIM1 8.65 μM (Ki) HIPK2 15.25 μM (Ki) DYRK1A 11.9 μM (Ki) Apoptosis
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CK2/ERK8-IN-1
CAS number：1085822-09-8 molecular formula：C11H9Br4N3O2
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Specs
| Chinese alias | CK2/ERK8 合一 | ||
| English alias | GTPL8140 | TMCB | CK2/ERK8-IN-1 | Casein Kinase II Inhibitor VI | 2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid | [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid | 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-be | ||
| CAS number | 1085822-09-8 | molecular formula | C11H9Br4N3O2 |
| molecular weight | 534.82 g/mol | Exact mass | ≥99% |
| PSA | 58.400 Ų | logp | 4.4 |
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