compound introduction
IRF1-IN-2 (Compound I-19) 是一种IRF1抑制剂。IRF1-IN-2 可减少 IRF1 对 CASP1 启动子的招募。IRF1-IN-2 抑制细胞死亡信号通路 (即抑制Caspase 1、GSDMD、IL-1和PARP1的裂解；抑制TKB1的 磷酸化，上调GPX4并下调FACL4)。IRF1-IN-2 对电离辐射引起的皮肤炎症性损伤有保护作用。
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2-methoxy-N-[4-(1-pyrrolidinylsulfonyl)phenyl]benzamide
CAS number：708245-32-3 molecular formula：C18H20N2O4S
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 708245-32-3 | molecular formula | C18H20N2O4S |
| molecular weight | 360.400 g/mol | Exact mass | ≥99% |
| PSA | 84.100 Ų | logp | 3.2 |
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