compound introduction
CDDO-TFEA (RTA 404; TP-500) 是 CDDO 的三氟乙酰胺衍生物，具有增强的穿过血脑屏障的能力。CDDO 是一种Nrf2激活剂，可抑制增殖并诱导各种癌细胞分化和凋亡。CDDO-TFEA 可以增强各种神经退行性疾病模型中的 Nrf2 表达和信号传导，包括模拟多发性硬化症、肌萎缩侧索硬化症和亨廷顿氏病的模型。CDDO-TFEA 诱导尤文氏肉瘤和神经母细胞瘤细胞系凋亡，阻止集落形成，IC50值范围为 85-170 nM。
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Cddo-tfea
CAS number：932730-52-4 molecular formula：
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 932730-52-4 | molecular formula | |
| molecular weight | 572.700 g/mol | Exact mass | - |
| PSA | 87.000 Ų | logp | 7.3 |
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