LQZ-7F 是一种生存素二聚化 (survivindimerization) 抑制剂,可在前列腺癌细胞中诱导自发细胞凋亡 (apoptosis) 并与多西紫杉醇协同作用。LQZ-7F 剂量依赖性地抑制 PC-3 和 C4-2 细胞的存活,IC50分别为 2.99 和 2.47 µM。
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4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo[7.7.0.0^{2,7}.0^{11,15}]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide
CAS number:354543-09-2 molecular formula:C14H7N9O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 354543-09-2 | molecular formula | C14H7N9O3 |
| molecular weight | 349.26 g/mol | Exact mass | - |
| PSA | 165.000 Ų | logp | 2.2 |
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