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4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo[7.7.0.0^{2,7}.0^{11,15}]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide

CAS number:354543-09-2    molecular formula:C14H7N9O3

overview

compound introduction

LQZ-7F 是一种生存素二聚化 (survivindimerization) 抑制剂,可在前列腺癌细胞中诱导自发细胞凋亡 (apoptosis) 并与多西紫杉醇协同作用。LQZ-7F 剂量依赖性地抑制 PC-3 和 C4-2 细胞的存活,IC50分别为 2.99 和 2.47 µM。

Specs

Chinese alias-
English alias-
CAS number354543-09-2molecular formulaC14H7N9O3
molecular weight349.26 g/molExact mass-
PSA165.000 Ųlogp2.2

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