N6F11 是一种选择性铁死亡 (ferroptosis) 诱导剂,可以通过靶向 TRIM25 介导的GPX4降解,选择性地诱导癌细胞发生铁死亡 (ferroptosis),同时对免疫细胞没有影响。N6F11 启动了依赖 HMGB1 的肿瘤免疫,由 CD8+T 细胞介导。
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2-(chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one
CAS number:851398-76-0 molecular formula:C13H8Cl2N2OS
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 851398-76-0 | molecular formula | C13H8Cl2N2OS |
| molecular weight | 311.2 g/mol | Exact mass | ≥98% |
| PSA | 69.700 Ų | logp | 3.6 |
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