Thiodigalactoside (TDG) 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。 D-Galactopyranosyl-β- D-thiogalactopyranoside (Thiodigalactoside) is a compound belonging to the dihexoses (disaccharides containing two hexose carbohydrates). Thiodigalactoside is known to target galectin-1, heat-labile enterotoxin b chain, neurocan core protein, and lactose permease.|D-Galactopyranosyl-β- D-thiogalactopyranoside is often used to study galectins, a family of glycan-binding lectins with diverse regulatory roles in physiological processes. Galectins have significant roles in inflammation and cancer. Thiodigalactoside is a diglycan that binds galectins-1, -3, -8, and -9 with Kd values between 24 and 78 μM. It is used to investigate the roles of these galectins in cell signaling and carcinogenesis.
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D-Galactopyranosyl-β-D-thiogalactopyranoside
CAS number：51555-87-4 molecular formula：C12H22O10S
overview
compound introduction
Specs
| Chinese alias | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫基双(2-(羟甲基)四氢-2H-吡喃-3,4,5-三醇) | ||
| English alias | (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyloxane-3,4,5-triol | Thiodigalactoside | Tdg cpd | D-Galactopyranosylthio-β-D-galactopyranoside | β-D-Galactopyranosyl 1-thio-β-D-galactopyranoside | | ||
| CAS number | 51555-87-4 | molecular formula | C12H22O10S |
| molecular weight | 358.36 g/mol | Exact mass | ≥98% |
| PSA | 206.000 Ų | logp | -3.4 |
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