CAS number：2249801-12-3 molecular formula：C22H14Cl2N4O
Information MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor ofmyeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression oftumor necrosis factor alpha (TNF-α)andinterleukin-6 (IL-6)in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively. Targets TLR4 ; IL-6 (Cell-free assay); TNF-α (Cell-free assay) ; 0.53 μM; 0.89 μM
| Chinese alias | N-(3-(1H-吲哚-5-基)-1H-吲唑-5-基)-2,6-二氯苯甲酰胺 | ||
| English alias | N-(3-(1H-Indol-5-yl)-1H-indazol-5-yl)-2,6-dichlorobenzamide | ||
| CAS number | 2249801-12-3 | molecular formula | C22H14Cl2N4O |
| molecular weight | 421.28 g/mol | Exact mass | - |
| PSA | 73.600 Ų | logp | 5.4 |
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