产品介绍： MSX-122是一种新型的CXCR4部分拮抗剂，IC50约为10 nM。 Information MSX-122 is a novel small molecule and partialCXCR4antagonist (IC50~10 nM). Targets CXCR4 ~10 nM In vitro MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux). In vivo MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo. Cell Research(from reference) Cell lines：MDA-MB-231 cells Concentrations：1, 10, 100, and 1000 nM Incubation Time：15 mins
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MSX-122
CAS number：897657-95-3 molecular formula：C16H16N6
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| Chinese alias | N1,N4-二-2-嘧啶基-1,4-苯二甲胺 | ||
| English alias | Q27264343 | XKB65795 | UNII-69D634Q702 | BDBM194510 | DB12715 | N,N'-(1,4-phenylenebis(methylene))bis(pyrimidin-2-amine) | FT-0699836 | AKOS030526974 | A861074 | EX-A784 | 69D634Q702 | BCP16282 | MSX 122 [WHO-DD] | MS-24180 | SB19805 | MSX 122 | MSX122 | | ||
| CAS number | 897657-95-3 | molecular formula | C16H16N6 |
| molecular weight | 292.34 g/mol | Exact mass | 10mM in DMSO |
| PSA | 75.600 Ų | logp | 2.1 |
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