Information Motolimod (VTX-2337) Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. Targets TLR8 100 nM(EC50) In vitro VTX-2337 stimulates the production of both TNFα with EC50 of 140 nM and IL-12 with EC50 of 120 nM in PBMCs. In monocytes and mDCs, VTX-2337 selectively induces the production of TNFα and IL-12 via NF-κB activation. VTX-2337 also stimulates IFNγ production from NK cells, augments the lytic function of NK cells and enhances ADCC. In vivo In an ovarian cancer mouse model, TX-2337 enhances the effect of pegylated liposomal doxorubicin (PLD). Cell Research(from reference) Cell lines：PBMCs or purified NK cells Concentrations：~500 nM Incubation Time：48 h
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Motolimod (VTX-2337)
CAS number：926927-61-9 molecular formula：C28H34N4O2
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| Chinese alias | 莫托利莫德(VTX-2337) | ||
| English alias | 2-amino-N,N-dipropyl-8-[4-(pyrrolidine-1-carbonyl)phenyl]-3H-1-benzazepine-4-carboxamide | 3H-1-Benzazepine-4-carboxamide, 2-amino-n,N-dipropyl-8-(4-(1-pyrrolidinylcarbonyl)phenyl)- | AKOS027422467 | EX-A1102 | GTPL9026 | D10716 | MOTOLIMOD [USAN] | s7161 | ||
| CAS number | 926927-61-9 | molecular formula | C28H34N4O2 |
| molecular weight | 458.6 g/mol | Exact mass | - |
| PSA | 79.000 Ų | logp | 3.854 |
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